The latest air strike took place in the Caribbean Sea, amid growing concerns about human rights violations under Trump.
The United States has announced its 10th missile strike on a maritime vessel accused of trafficking illegal narcotics, killing all six people on board.
Friday’s attack brings the total known number of dead since the bombing campaign began to 43.
It also marks an escalating pace to the air strikes: The US government has announced three strikes this week in as many days.
Defense Secretary Pete Hegseth broke the news of the latest bombing on his social media, identifying the victims as members of the Venezuela-based gang Tren de Aragua.
He also indicated that President Donald Trump himself had once again given authorisation for the strike, which allegedly took place in international waters in the Caribbean Sea.
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