US president Donal Trump at the White House on Tuesday after signing an executive order to use AI in paediatric cancer research. Photograph: Francis Chung/Politico/Bloomberg

Washington braced for a fast-approaching government shutdown on Tuesday, as Republicans and Democrats appeared unlikely to reach an agreement that would extend funding past a midnight deadline.

The Republican-controlled Senate is expected to vote on a temporary spending bill that has failed once already, with no sign that a second vote will bring success.

Democrats want to modify the must-pass spending bill to extend health benefits for millions of Americans that are due to expire at the end of the year. Republicans say they must tackle that issue separately.

US president Donald Trump said layoffs were an inevitability if the government shuts down. At the signing of an executive order to use AI in paediatric cancer research, Mr Trump was asked w

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