A UPS cargo plane crashed and exploded in a massive fireball Tuesday while taking off from the company's global aviation hub in Louisville, Kentucky, killing at least three people and injuring 11 β€” numbers that were likely to grow, the state's governor said.

The plane crashed about 5:15 p.m. as it was departing for Honolulu from Louisville's Muhammad Ali International Airport, the Federal Aviation Administration said.

"Right now we believe we have at least three fatalities, though I believe that number is going to get larger.

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